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ANSTO Publications Online

Welcome to the ANSTO Institutional Repository known as APO.

The APO database has been migrated to version 8.3. The functionality has changed, but the content remains the same.

ANSTO Publications Online is a digital repository for publications authored by ANSTO staff since 2007. The Repository also contains ANSTO Publications, such as Reports and Promotional Material. ANSTO publications prior to 2007 continue to be added progressively as they are in identified in the library. ANSTO authors can be identified under a single point of entry within the database. The citation is as it appears on the item, even with incorrect spelling, which is marked by (sic) or with additional notes in the description field.

If items are only held in hardcopy in the ANSTO Library collection notes are being added to the item to identify the Dewey Call number: as DDC followed by the number.

APO will be integrated with the Research Information System which is currently being implemented at ANSTO. The flow on effect will be permission to publish, which should allow pre-prints and post prints to be added where content is locked behind a paywall. To determine which version can be added to APO authors should check Sherpa Romeo. ANSTO research is increasingly being published in open access due mainly to the Council of Australian University Librarians read and publish agreements, and some direct publisher agreements with our organisation. In addition, open access items are also facilitated through collaboration and open access agreements with overseas authors such as Plan S.

ANSTO authors are encouraged to use a CC-BY licence when publishing open access. Statistics have been returned to the database and are now visible to users to show item usage and where this usage is coming from.

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    A robotic treatment delivery system to facilitate dynamic conformal synchrotron radiotherapy
    (Wiley, 2025-06) Barnes, MJ; Afshar, N; Batty, T; Fiala, T; Cameron, M; Hausermann, D; Hardcastle, N; Lerch, M
    Background In clinical radiotherapy, the patient remains static during treatment and only the source is dynamically manipulated. In synchrotron radiotherapy, the beam is fixed, and is horizontally wide and vertically small, requiring the patient to be moved through the beam to ensure full target coverage, while shaping the field to conform to the target. No clinical system exists that performs both dynamic motion of the patient and dynamic shaping of the beam. Purpose We developed and tested a new dynamic treatment delivery system capable of delivering conformal fields with a robotic patient positioning system for use on the Imaging and Medical Beamline (IMBL) at the Australian Nuclear Science and Technology Organisation, Australian Synchrotron. Methods An industrial robotic manipulator was modified to enable dynamic radiotherapy treatments on IMBL. The robot, combined with a carbon-fiber treatment couch-top and a recently developed dynamic collimator, formed the basis of the new treatment delivery system. To synchronize the motions of the robot and collimator, a real-time, hardware-based event-handling system was utilized. To test the system, a ball bearing in a medical physics phantom was treated with circular fields ranging from 5 to 40 mm in diameter and at treatment speeds from 2 to 50 mm s−1. The position of the ball bearing was compared to the center of the circular fields and the positional and temporal accuracy of the treatment delivery system was assessed, and appropriate treatment margins for the system were determined. Results The vertical position of the ball bearing varied with treatment delivery speed (−1.06 to 0.93 mm) while the horizontal position remained consistent (−0.05 to 0.09 mm). The time-delay between the robot and the collimator remained consistent (−35.5 ms to 18.5 ms) at treatment speeds above 2 mms−1. Data at 2 mm⁢s−1 was right at the edge of both the robot capabilities and the analysis technique, and had larger variations in timing (0.0 ms to 57.9 ms). Horizontal margins of 0.51 mm and vertical margins of up to 2.3 mm were calculated for the treatment delivery system. Conclusions We have implemented the first robotic treatment delivery system for synchrotron radiotherapy treatments. The largest errors were observed in the direction of motion of the patient through the beam and with future improvements, can be reduced. The system was both accurate and repeatable and is ready to support future treatments on IMBL. © 2025 The Author(s). Medical Physics published by Wiley Periodicals LLC on behalf of American Association of Physicists in Medicine. Open Access CC BY 4.0.
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    Structural and thermal diffusivity analysis of an organoferroelastic crystal showing scissor-like two-directional deformation induced by uniaxial compression
    (American Chemical Society (ACS), 2023-10-15) Ranjan, S; Ryu, M; Morioka, R; Kamegaki, S; Ng, SH; Smith, D; Vongsvivut, JP; Tobin, MJ; Juodkazis, S; Morikawa, J; Takamizawa, S
    A two-directional ferroelastic deformation in organic crystals is unprecedented owing to its anisotropic crystal packing, in contrast to isotropic symmetrical packing in inorganic compounds and polymers. Thereby, finding and constructing multidirectional ferroelastic deformations in organic compounds is undoubtedly complex and at once calls for deep comprehension. Herein, we demonstrate the first example of a two-directional ferroelastic deformation with a unique scissor-like movement in single crystals of trans-3-hexenedioic acid by the application of uniaxial compression stress. A detailed structural investigation of the mechanical deformation at the macroscopic and microscopic levels by three distinct force measurement techniques (including shear and three-point bending test), single crystal X-ray diffraction techniques, and polarized synchrotron-FTIR microspectroscopy highlighted that mechanical twinning promoted the deformation. The presence of two crystallographically equivalent faces and the herringbone arrangement promoted the two-directional ferroelastic deformation. In addition, anisotropic heat transfer properties in the parent and the deformed domains were investigated by thermal diffusivity measurement on all three axes using microscale temperature-wave analysis (μ-TWA). A correlation between the anisotropic structural arrangement and the difference in thermal diffusivity and mechanical behavior in the two-directional organoferroelastic deformation could be established. The structural and molecular level information from this two-directional ferroelastic deformation would lead to a more profound understanding of the structure-property relationship in multidirectional deformation in organic crystals. © 2023 American Chemical Society.
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    Direct interaction of whole-inactivated influenza A and pneumococcal vaccines enhances influenza-specific immunity
    (Springer Nature, 2019-05-20) David, SC; Norton, T; Tyllis, T; Wilson, JJ; Singleton, EV; Laan, Z; Davies, J; Hirst, TR; Comerford, I; McColl, SR; Paton, JC; Alsharifi, M
    The upper respiratory tract is continuously exposed to a vast array of potentially pathogenic viruses and bacteria. Influenza A virus (IAV) has particular synergism with the commensal bacterium Streptococcus pneumoniae in this niche, and co-infection exacerbates pathogenicity and causes significant mortality. However, it is not known whether this synergism is associated with a direct interaction between the two pathogens. We have previously reported that co-administration of a whole-inactivated IAV vaccine (γ-Flu) with a whole-inactivated pneumococcal vaccine (γ-PN) enhances pneumococcal-specific responses. In this study, we show that mucosal co-administration of γ-Flu and γ-PN similarly augments IAV-specific immunity, particularly tissue-resident memory cell responses in the lung. In addition, our in vitro analysis revealed that S. pneumoniae directly interacts with both γ-Flu and with live IAV, facilitating increased uptake by macrophages as well as increased infection of epithelial cells by IAV. These observations provide an additional explanation for the synergistic pathogenicity of IAV and S. pneumoniae, as well as heralding the prospect of exploiting the phenomenon to develop better vaccine strategies for both pathogens. © 2019, The Author(s), under exclusive licence to Springer Nature Limited.
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    Appendicular morphology of Mesenosaurus efremovi and the earliest occurrence of a calcaneal tuberosity
    (Taylor & Francis, 2025-11-17) Rowe, DCT; Young, JM; Boyd, BP; Bevitt, JJ; Reisz, RR
    The Richards Spur locality in Oklahoma, U.S.A. is renowned for its diverse assemblage of early Permian terrestrial tetrapods, including the varanopid Mesenosaurus efremovi. Recent quarrying operations yielded numerous skeletal remains attributed to this taxon, including partially articulated cranial and postcranial remains with the latter being especially important given the comparatively minimal description in previous studies. The specimens used in this study, including a superbly preserved hindfoot, all represent approximately the same growth stage, and collectively reveal the morphology of the entire pelvis and hindlimb in unprecedented detail. CT data, analysed using the segmentation software Avizo, was utilised to examine the hindfoot specimen. As in other varanopids, the limb proportions of this predator are gracile, the bones being more slender than in the similarly well-known taxon Varanops. In addition, M. efremovi exhibits unique ankle morphologies including a highly robust astragalus with a massive transverse ridge and a medially oriented tibial articular surface, a pronounced lateral calcaneal tuberosity and an enlarged fourth tarsal. These likely diagnostic features of Mesenosaurus point to specialised lower limb design for rapid locomotion, and further confirms its close relationship to the middle Permian M. romeri from Russia and consequent temporal longevity of this varanopid genus.
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    Correlative imaging reveals metal dyshomeostasis and altered zinc coordination environments in a pre-clinical Type 2 diabetes model
    (Oxford University Press (OUP), 2026-01-02) Ellison, G; Sharif, A; Willans, M; Hollings, A; Takechi, R; Bambery, KR; Mitchell, VD; Howard, DL; Hackett, MJ
    Zinc ions are highly abundant in pancreatic islet tissue, and multiple lines of evidence link loss of zinc homeostasis to poor glucose regulation in both type 1 and type 2 diabetes. Two major islet zinc-binding proteins, insulin and metallothionein, play crucial roles in beta cell function and glucose regulation. Here we used X-ray fluorescence microscopy (XFM) to map zinc and five additional elements (Cl, K, Ca, Fe, and Cu) to compare the metallome of exocrine, peri-islet and islet regions in young and old, non-diabetic control and diabetic (db/db) mice. We also determined the main forms of zinc found in pancreatic tissue using X-ray absorption near-edge structure (XANES) spectroscopic imaging. This allowed investigation of the relationship between zinc speciation and its protein ligands using correlative immunofluorescent imaging to assess whether zinc coordination may play a role in diabetes pathology. The anticipated depletion of zinc in young diabetic islets was accompanied by a significant decrease in insulin expression and increase in metallothionein expression. A parallel change in the contribution of cysteine vs histidine zinc speciation was also observed. Counter-intuitively, zinc abundance and speciation appeared to normalise in old diabetic animals with more advanced disease, despite large differences in labile zinc-binding protein content. These results are consistent with disrupted zinc coordination, where metallothionein-regulated muffling to minimise ionic activity is overwhelmed and zinc binds to unidentified ligands in histidine-like conformations. This opens future study questions focussed on the complex interplay between labile zinc, metallothionein, and oxidative mechanisms that may interfere with normal zinc homeostasis. © The Author(s) 2025. Published by Oxford University Press. Open Access CC BY 4.0.