Olanzapine differentially affects 5-HT2A (and 2C) receptor mRNA expression in the rat brain

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Date
2006-08-10
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Elsevier Science BV
Abstract
This study examined regional changes in rat brain mRNA levels encoding 5-HT2A and 5-HT2C receptors following chronic olanzapine treatment. The immediate effect (2 h after the last treatment) was a down-regulation of 5-HT2A receptor mRNA expression, predominantly in the hypothalamus, limbic system and striatum, while a rebound effect was observed 48 h later. 5-HT2C receptor mRNA expressions were decreased in the substantia nigra. Correlations between 5-HT2A receptor mRNA expression and total food intake, weight gain and energy efficiency were observed. © 2006, Elsevier Ltd.
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Keywords
Weight, Metabolic diseases, Dopamine, Serotonin, Genes, Diet
Citation
Huang, X. F., Han, M., Huang, X., Zavitsanou, K., & Deng, C. (2006). Olanzapine differentially affects 5-HT2A (and 2C) receptor mRNA expression in the rat brain. Behavioural Brain Research, 171(2), 355-362. doi:10.1016/j.bbr.2006.03.040
URI
http://dx.doi.org/10.1016/j.bbr.2006.03.040
 http://apo.ansto.gov.au/dspace/handle/10238/5564
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