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Title: Olanzapine differentially affects 5-HT2A (and 2C) receptor mRNA expression in the rat brain
Authors: Huang, XF
Han, M
Huang, X
Zavitsanou, K
Deng, C
Keywords: WEIGHT
Issue Date: 10-Aug-2006
Citation: Huang, X. F., Han, M., Huang, X., Zavitsanou, K., & Deng, C. (2006). Olanzapine differentially affects 5-HT2A (and 2C) receptor mRNA expression in the rat brain. Behavioural Brain Research, 171(2), 355-362.
Abstract: This study examined regional changes in rat brain mRNA levels encoding 5-HT2A and 5-HT2C receptors following chronic olanzapine treatment. The immediate effect (2 h after the last treatment) was a down-regulation of 5-HT2A receptor mRNA expression, predominantly in the hypothalamus, limbic system and striatum, while a rebound effect was observed 48 h later. 5-HT2C receptor mRNA expressions were decreased in the substantia nigra. Correlations between 5-HT2A receptor mRNA expression and total food intake, weight gain and energy efficiency were observed. © 2006, Elsevier Ltd.
ISSN: 0166-4328
Appears in Collections:Journal Articles

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