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|Title: ||Optimisation of [11C]raclopride production using a synthra GPextent system|
|Authors: ||Perkins, G|
|Issue Date: ||1-Dec-2014|
|Publisher: ||Bentham Science Publishers|
|Citation: ||Perkins, G., Sheth, R., Greguric, I., & Pascali, G. (2014). Optimisation of [11C] raclopride production using a synthra gpextent system. Current radiopharmaceuticals, 7(2), 100-106. doi:10.2174/1874471007666141021111635|
|Abstract: ||The dopamine D2 receptor radiotracer [(11)C]Raclopride is used extensively in clinical and preclinical imaging. Currently, a wide range of methods to produce [(11)C]Raclopride have been developed using traditional vessel reactions as well as cartridge or captive solvent. This work reports the optimisation of the production of [(11)C]Raclopride using a Synthra GPextent, comparing various methods. With optimised conditions, we were able to obtain 4±2% (ndc) yield of [(11)C]Raclopride (100 GBq [(11)C]CO2, n = 42) in 25 min. The radiochemical purity was >95% with specific activities of 135±41 MBq/nmol at end of synthesis. © 2014 Bentham Science Publishers|
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