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Please use this identifier to cite or link to this item: http://apo.ansto.gov.au/dspace/handle/10238/9195

Title: Microfluidic implementation of Ru-catalyzed methylation of amines using CO2 as carbon source
Authors: Perkins, G
Khatib, O
Peterson, M
Kallinen, A
Pham, TQ
Ung, A
Greguric, I
Pascali, G
Keywords: Carbon 11
Methylation
Carbon dioxide
Ruthenium
Catalyst
Amines
Issue Date: 22-Jun-2016
Publisher: Akadémiai Kiadó Zrt
Citation: Perkins, G., Khatib, O., Peterson, M., Kallinen, A., Pham, T., Ung, A., Greguric, I & Pascali, G. (2016). Microfluidic implementation of Ru-catalyzed methylation of amines using CO2 as carbon source. Journal of Flow Chemistry, 6(4), 302-308. doi:10.1556/1846.2016.00010
Abstract: Carbon dioxide chemistry is an area of continuing growth in recent times, due to socioeconomic and environmental reasons. Several methods have now been reported for obtaining N-methylation on primary and secondary amines directly from CO2. We have translated in two microfluidic setups (Slug Flow [SF] and Tube-in-Tube [TiT]) a ruthenium (Ru)-catalyzed process previously reported using a pressure vessel. Here, we demonstrate how the SF approach is more efficient but requires more input to reach a steady state, while the TiT system is less efficient but more tuneable.We have tested these processes on three model amines and two radiopharmaceutical precursors that are routinely used in 11C chemistry. The microfluidic processes tested are also potentially more efficient than the pressure vessel counterpart, in terms of amount of Ru catalyst needed (1% vs. 10%) and projected reaction completion time. © 2016 Akadémiai Kiadó Zrt.
URI: https://doi.org/10.1556/1846.2016.00010
http://apo.ansto.gov.au/dspace/handle/10238/9195
ISSN: 2062-249X
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