[18F]Fluorination optimisation and the fully automated production of [18F]MEL050 using a microfluidic system
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Date
2014-06-06
Journal Title
Journal ISSN
Volume Title
Publisher
CSIRO Publishing
Abstract
The [18F]radiolabelling of the melanin-targeting positron-emission tomography radiotracer [18F]MEL050 was rapidly optimised using a commercial continuous-flow microfluidic system. The optimal [18F]fluorination incorporation conditions were then translated to production-scale experiments (35–150 GBq) suitable for preclinical imaging, complete with automated HPLC–solid phase extraction purification and formulation. [18F]MEL050 was obtained in 43 ± 10 % radiochemical yield in ~50 min. © 2015 CSIRO Publishing.
Description
Keywords
Fluorination, Melanin, Positron computed tomography, Temperature range 0400-1000 K, Fluorine, High-performance liquid chromatography, Radiochemical analysis
Citation
Matesic, L., Kallinen, A., Wyatt, N. A., Pham, T. Q., Greguric, I., & Pascali, G. (2015). [18F] Fluorination optimisation and the fully automated production of [18F] MEL050 using a microfluidic system. Australian Journal of Chemistry, 68(1), 69-71. doi:10.1071/CH14130