One‐step radiosynthesis of 4‐nitrophenyl 2‐[18F]fluoropropionate ([18F]NFP); improved preparation of radiolabeled peptides for PET imaging

Haskali, M; Roselt, PD; Karas, JA; Noonan, W; Wichmann, CW; Katsifis, A; Hicks, RJ; Hutton, CA

One‐step radiosynthesis of 4‐nitrophenyl 2‐[18F]fluoropropionate ([18F]NFP); improved preparation of radiolabeled peptides for PET imaging

Date

2013-09-16

Authors

Publisher

John Wiley & Sons, Ltd.

Abstract

The versatile 18F‐labeled prosthetic group, 4‐nitrophenyl 2‐[18F]fluoropropionate ([18F]NFP), was synthesized in a single step in 45 min from 4‐nitrophenyl 2‐bromopropionate, with a decay corrected radiochemical yield of 26.2% ± 2.2%. Employing this improved synthesis of [18F]NFP, [18F]GalactoRGD — the current ‘gold standard’ tracer for imaging the expression of αVβ3 integrin — was prepared with high specific activity in 90 min and 20% decay corrected radiochemical yield from [18F]fluoride. © 2013 John Wiley & Sons, Ltd.

Keywords

Positron computed tomography, Peptides, Fluorides, Proteins, Neoplasms, Diseases

Citation

Haskali, M. B., Roselt, P. D., Karas, J. A., Noonan, W., Wichmann, C. W., Katsifis, A., Hicks, R. J., & Hutton, C. A. (2013). One‐step radiosynthesis of 4‐nitrophenyl 2‐[18F] fluoropropionate ([18F] NFP); improved preparation of radiolabeled peptides for PET imaging. Journal of Labelled Compounds and Radiopharmaceuticals, 56(14), 726-730. doi:doi.org/10.1002/jlcr.3111