In vivo PET imaging with [18F]FDG to explain improved glucose uptake in an apolipoprotein A-I treated mouse model of diabetes

Type 2 diabetes is characterised by decreased HDL levels, as well as the level of apolipoprotein A-I (apoA-I), the main apolipoprotein of HDLs. Pharmacological elevation of HDL and apoA-I levels is associated with improved glycaemic control in patients with type 2 diabetes. This is partly due to improved glucose uptake in skeletal muscle.© 2016 Springer Nature

Keywords

Diabetes mellitus, Fluorodeoxyglucose, Insulin, Kinetics, Positron computed tomography, Simulation, Lipoproteins, Radiopharmaceuticals, Phosphorylation

Citation

Cochran, B. J., Ryder, W. J., Parmar, A., Tang, S., Reilhac, A., Arthur, A., Charil, A., Hamze, H., Barter, P. J., Kritharides, L. Meikle, S. R., Grégoire, M. C. & Rye, K. (2016). In vivo PET imaging with [18F] FDG to explain improved glucose uptake in an apolipoprotein AI treated mouse model of diabetes. Diabetologia, 59(9), 1977-1984. doi:10.1007/s00125-016-3993-5