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Title: Influence of metal ions on the Ga-68-labeling of dotatate
Authors: Oehlke, E
Le, VS
Lengkeek, N
Pellegrini, P
Jackson, T
Gregurica, I
Weiner, R
Keywords: CATIONS
Issue Date: 1-Dec-2013
Publisher: Elsevier
Citation: Oehlke, E., Le, V. S., Lengkeek, N., Pellegrini, P., Jackson, T., Greguric, I., & Weiner, R. (2013). Influence of metal ions on the Ga-68-labeling of DOTATATE. Applied Radiation and Isotopes, 82, 232-238.
Abstract: The influence of metal cations (Fe3+, Fe2+, In3+, Cu2+, Ca2+, Al3+, Co2+, Lu3+, Ni2+, Pb2+, Ti4+, Y3+, Yb3+, Zn2+, and Zr4+) on the radiolabeling yield of [68Ga(DOTATATE)] was evaluated. Our most important observation was that, within our experimental limit, the metal ion/ligand ratio plays a critical role on the influence of most metal ions. More in-depth studies, with Cu2+ and Fe3+, revealed that reaction temperature and concentration changes have little effect, but speciation changes with pH are crucial. Furthermore, we found that [68Ga(DOTATATE)] is stable in the presence of high concentrations of Fe3+, Zn2+ and Pb2+, but transmetalates with Cu2+ at 95 °C. © 2013, Elsevier Ltd.
ISSN: 0969-8043
Appears in Collections:Journal Articles

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