ANSTO Publications Online >
Journal Publications >
Journal Articles >

Please use this identifier to cite or link to this item: http://apo.ansto.gov.au/dspace/handle/10238/5879

Title: Comparison of cannabinoid CB1 receptor binding in adolescent and adult rats: a Positron Emission Tomography study using [18F]MK-947.
Authors: Verdurand, M
Nguyen, V
Stark, D
Zahra, D
Gregoire, M-C
Greguric, I
Zavitsanou, K
Keywords: MAMMALS
ADOLESCENTS
IN VIVO
POSITRON COMPUTED TOMOGRAPHY
TOMOGRAPHY
AUTORADIOGRAPHY
Issue Date: 1-Jan-2011
Publisher: Hindawi Publishing Corporation
Citation: Verdurand, M., Nguyen, V., Stark, D., Zahra, D., Gregoire, M-C., Greguric, I., & Zavitsanou, K. (2011). Comparison of cannabinoid CB1 receptor binding in adolescent and adult rats: a Positron Emission Tomography study using [18F]MK-947. International Journal of Molecular Imaging, 2011, Article Number 548123.
Abstract: Despite the important role of cannabinoid CB1 receptors (CB1R) in brain development, little is known about their status during adolescence, a critical period for both the development of psychosis and for initiation to substance abuse. In the present study, we assessed the ontogeny of CB1R in adolescent and adult rats in vivo using positron emission tomography with [18F]MK-9470. Analysis of covariance (ANCOVA) to control for body weight that would potentially influence [18F]MK-9470 values between the two groups revealed a main effect of age ( 𝐹 ( 1 , 1 0 9 ) = 5 . 0 , 𝑃 = 0 . 0 2 ) on [18F]MK-9470 absolute binding (calculated as percentage of injected dose) with adult estimated marginal means being higher compared to adolescents amongst 11 brain regions. This finding was confirmed using in vitro autoradiography with [3H]CP55,940 ( 𝐹 ( 1 0 , 9 9 ) = 1 4 0 . 1 , 𝑃 < 0 . 0 0 0 1 ). This ontogenetic pattern, suggesting increase of CB1R during the transition from adolescence to adulthood, is the opposite of most other neuroreceptor systems undergoing pruning during this period. Copyright © 2011 Mathieu Verdurand et al.
URI: http://dx.doi.org/10.1155/2011/548123
http://apo.ansto.gov.au/dspace/handle/10238/5879
ISSN: 2090-1712
Appears in Collections:Journal Articles

Files in This Item:

There are no files associated with this item.

Items in APO are protected by copyright, with all rights reserved, unless otherwise indicated.

 

Valid XHTML 1.0! DSpace Software Copyright © 2002-2010  Duraspace - Feedback