ANSTO Publications Online >
Journal Publications >
Journal Articles >

Please use this identifier to cite or link to this item: http://apo.ansto.gov.au/dspace/handle/10238/5500

Title: Opposing short- and long-term effects on muscarinic M1/4 receptor binding following chronic phencyclidine treatment
Authors: Newell, KA
Zavitsanou, K
Huang, XF
Keywords: ACETYLCHOLINE
RATS
AUTORADIOGRAPHY
ANIMALS
BRAIN
ATROPINE
Issue Date: 1-May-2007
Publisher: WILEY-LISS
Citation: Newell, K. A., Zavitsanou, K., & Huang, X. F. (2007). Opposing short- and long-term effects on muscarinic M1/4 receptor binding following chronic phencyclidine treatment. Journal of Neuroscience Research, 85(6), 1358-1363.
Abstract: Phencyclidine (PCP) is a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist. Several studies have demonstrated that chronic NMDA receptor antagonist treatment in humans and animals can cause long-term behavioral changes that are reminiscent of negative and cognitive schizophrenia-like symptoms. The muscarinic cholinergic system, which is associated with cognitive functions, has been hypothesized to contribute to PCP's mechanism of action. No study, however, has examined the status of M1/4 receptors in the PCP model of schizophrenia. The aim of the present study was to investigate the effects of chronic (14 day) PCP treatment on mouse brain M1/4 receptors in the short term (1 hr and 24 hr) and long term (14 days) after last PCP administration. [3H]pirenzepine was used to target M1/4 receptors. In the short term following chronic PCP treatment, M1/4 binding was significantly increased in regions of the limbic system, caudate-putamen, cortex, and thalamus (ranging from 56% to 368%), compared with saline-treated mice. There were no differences in binding between mice treated with PCP for 14 days and sacrificed 1 hr or 24 hr after the final PCP treatment. In the long term following chronic PCP treatment, M1/4 binding was significantly decreased in all of the above-mentioned brain regions (ranging from 31% to 72%), except in the thalamus, which showed no change. These findings in the long-term group are similar to those reported in post-mortem studies of patients suffering from schizophrenia. © 2007, John Wiley & Sons, Inc.
URI: http://dx.doi.org/10.1002/jnr.21247
http://apo.ansto.gov.au/dspace/handle/10238/5500
ISSN: 0360-4012
Appears in Collections:Journal Articles

Files in This Item:

There are no files associated with this item.

Items in APO are protected by copyright, with all rights reserved, unless otherwise indicated.

 

Valid XHTML 1.0! DSpace Software Copyright © 2002-2010  Duraspace - Feedback