Synergic factors in murine nephrosis, demonstrated by computer techniques

Abstract

Simple environmental changes, including a whole, fresh diet, delayed the onset of the usual diseases of lungs and kidneys in laboratory rats. 'Spontaneous' nephrosis appears to develop from interactions involving inherent immune status, nurture, and environmental 'triggers', particularly inhalants. These methods could be adapted to toxicological investigations and the results suggest the need for new approaches in statistical and interpretative analyses.