ANSTO Publications Online >
Journal Publications >
Journal Articles >

Please use this identifier to cite or link to this item: http://apo.ansto.gov.au/dspace/handle/10238/5397

Title: Protein Surface and Core Dynamics Show Concerted Hydration-Dependent Activation
Authors: Wood, K
Gallat, FX
Otten, R
van Heel, AJ
Lethier, M
van Eijck, L
Moulin, M
Haertlein, M
Weik, M
Mulder, FAA
Keywords: HYDRATION
ISOTOPES
NEUTRON SPECTROSCOPY
PROTEINS
ENZYME ACTIVITY
MYOGLOBIN
LYSOZYME
GLASS
Issue Date: 1-Jan-2013
Publisher: WILEY-V C H VERLAG GMBH
Citation: Wood, K., Gallat, F. X., Otten, R., van Heel, A. J., Lethier, M., van Eijck, L., Moulin, M., Haertlein, M., Weik, M., & Mulder, F. A. A. (2013). Angewandte Chemie International Edition, 52(2), 665-668.
Abstract: By specifically labeling leucine/valine methyl groups and lysine side chains “inside” and “outside” dynamics of proteins on the nanosecond timescale are compared using neutron scattering (see picture). Surprisingly, both groups display similar dynamics as a function of temperature, and the buried hydrophobic core is sensitive to hydration and undergoes a dynamical transition. © 2013, Wiley-VCH Verlag GmbH & Co. KGaA
URI: http://dx.doi.org/10.1002/anie.201205898
http://apo.ansto.gov.au/dspace/handle/10238/5397
ISSN: 1433-7851
Appears in Collections:Journal Articles

Files in This Item:

There are no files associated with this item.

Items in APO are protected by copyright, with all rights reserved, unless otherwise indicated.

 

Valid XHTML 1.0! DSpace Software Copyright © 2002-2010  Duraspace - Feedback