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|Title: ||Synthesis of cephalosporin-3'-diazeniumdiolates: biofilm dispersing NO-donor prodrugs activated by b-lactamase|
|Authors: ||Yepuri, NR|
|Keywords: ||NITRIC OXIDE|
|Issue Date: ||1-Jan-2013|
|Publisher: ||Royal Society of Chemistry|
|Citation: ||Yepuri, N. R., Barraud, N., Mohammadi, N. S., Kardak, B. G., Kjelleberg, S., Rice, S. A., & Kelso, M. J. (2013). Synthesis of cephalosporin-3'-diazeniumdiolates: biofilm dispersing NO-donor prodrugs activated by b-lactamase. Chemical Communications, 49 (42), 4791-4793.|
|Abstract: ||Use of biofilm dispersing NO-donor compounds in combination with antibiotics has emerged as a promising new strategy for treating drug-resistant bacterial biofilm infections. This paper details the synthesis and preliminary evaluation of six cephalosporin-3[prime or minute]-diazeniumdiolates as biofilm-targeted NO-donor prodrugs. Each of the compounds is shown to selectively release NO following reaction with the bacteria-specific enzyme [small beta]-lactamase and to trigger dispersion of Pseudomonas aeruginosa biofilms in vitro. © 2013, Royal Society of Chemistry|
|Appears in Collections:||Journal Articles|
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