Unexpected low-temperature behaviour of piroxicam monohydrate
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Date
2013-03-18
Journal Title
Journal ISSN
Volume Title
Publisher
Wiley-VCH Verlag
Abstract
Upon cooling the monohydrate of the anti-inflammatory drug piroxicam shows reversible splitting. The cell also shows an irregular contraction over temperature and has a memory effect of its thermal history. This is due to strongly hydrogen bonded chains present in the monohydrate, which allow the crystal domains to contract separately from each other. © 2013, Wiley-VCH Verlag.
Description
Keywords
Neutron diffraction, Enthalpy, Crystals, Polycarbonates, Water, Drugs
Citation
Fucke, K., Edwards, A. J., Probert, M. R., Tallentire, S. E. Howard, J. A. K., & Steed, J. W. (2013). Unexpected low-temperature behaviour of piroxicam monohydrate. Chemical Physics and Physical Chemistry, 14 (4), 675-679. doi:10.1002/cphc.201200316