ANSTO Publications Online >
Journal Publications >
Journal Articles >

Please use this identifier to cite or link to this item: http://apo.ansto.gov.au/dspace/handle/10238/4125

Title: Differential Treatment Regimen-Related Effects of HU210 on CB(1) and D(2)-Like Receptor Functionality in the Rat Basal Ganglia
Authors: Nguyen, VH
Wang, H
Verdurand, M
Zavitsanou, K
Keywords: RECEPTORS
NEUTRON THERAPY
PROTEINS
Rats
BASAL METABOLISM
Autoradiography
Issue Date: 1-Feb-2012
Publisher: KARGER
Citation: Nguyen, V.H., Wang, H., Verdurand, M., Zavitsanous, K. (2011). Differential Treatment Regimen-Related Effects of HU210 on CB(1) and D(2)-Like Receptor Functionality in the Rat Basal Ganglia. Pharmacology, 89(1-2), 64-73.
Abstract: Background/Aims: Functional linkages between the cannabinoid CB(1) and the dopaminergic systems have been reported although the observations and the mechanisms hypothesizing their interactions at the G protein-coupled receptor (GPCR) functionality level are conflicting. Methods: Administration of a potent cannabinoid agonist, HU210, at various doses (25-100 μg/kg) and treatment regimens (1- to 14-day treatment) in rats was carried out to investigate the effect of HU210 treatment on the CB(1) and D(2)-like agonist-mediated GPCR activation. Results: The desensitizations (reduced coupling) of both D(2) agonist- and CB(1) agonist-mediated GPCR activation was found to be treatment duration dependent and region specific, suggesting implication of receptor tolerance and adaptation due to the cannabinoid treatment. The effect of HU210 on the CB(1) agonist-mediated GPCR desensitization in all treatment groups was not dose dependent. Conclusions: The desensitization of D(2)-like receptors found after a cannabinoid treatment in this study strengthens the evidence that the two neurotransmitter systems interact at the intercellular level; this interaction might occur via multiple mechanisms, which also vary according to region. Copyright © 2012 S. Karger AG, Basel.
URI: 0031-7012
http://apo.ansto.gov.au/dspace/handle/10238/4125
Appears in Collections:Journal Articles

Files in This Item:

There are no files associated with this item.

Items in APO are protected by copyright, with all rights reserved, unless otherwise indicated.

 

Valid XHTML 1.0! DSpace Software Copyright © 2002-2010  Duraspace - Feedback