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|Title: ||Tandem “Click” Reactions at Acetylene-Terminated Si(100) Monolayers|
|Authors: ||Ciampi, S|
|Keywords: ||X-ray spectroscopy|
X-ray photoelectron spectroscopy
|Issue Date: ||7-Jun-2011|
|Publisher: ||American Chemical Society|
|Citation: ||Ciampi, S., James, M., Michaels, & P., Gooding, J.J. (2011). Tandem “Click” Reactions at Acetylene-Terminated Si(100) Monolayers, Langmuir, 27(11), 6940-6949.|
|Abstract: ||We demonstrate a simple method for coupling alkynes to alkynes. The method involves tandem azideâ€“alkyne cycloaddition reactions (â€œclickâ€ chemistry) for the immobilization of 1-alkyne species onto an alkyne modified surface in a one-pot procedure. In the case presented, these reactions take place on a nonoxidized Si(100) surface although the approach is general for linking alkynes to alkynes. The applicability of the method in the preparation of electrically well-behaved functionalized surfaces is demonstrated by coupling an alkyne-tagged ferrocene species onto alkyne-terminated Si(100) surfaces. The utility of the approach in biotechnology is shown by constructing a DNA sensing interface by derivatization of the acetylenyl surface with commercially available alkyne-tagged oligonucleotides. Cyclic voltametry, electrochemical impedance spectroscopy, X-ray photoelectron spectroscopy, and X-ray reflectometry are used to characterize the coupling reactions and performance of the final modified surfaces. These data show that this synthetic protocol gives chemically well-defined, electronically well-behaved, and robust (bio)functionalized monolayers on silicon semiconducting surfaces. © 2010, American Chemical Society|
|Appears in Collections:||Journal Articles|
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