Preparation of PZC based 99m TC generator to be available for clinic for clinical application
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IAEA’s coordinated research project first research coordination meeting
Abstract
The performance of PZC was investigated for chromatographic Tc-99m generator preparation. Mo-adsorption of PZC in different Mo-solutions and Tc-99m elution of 99Mo-PZC column were studied. Mo- adsorption capacity of higher than 250mgMo/gPZC and Tc-99m elution yield of higher than 80% were achieved with PZC adsorbent. Mo-99 breakthrough of 0.02% and Molybdenum element breakthrough of around 5µg Mo/ml were found in Tc-99m eluate. A good relationship between the Mo-content of adsorption solution and the Mo-adsorption capacity, adsorption percentage, Mo-breakthrough and Tc-99m elution yield was found.
The column pre-loading procedure for the preparation of PZC based chromatographic Tc-99m generators were described in detail .
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Le, V.S. (2004). Preparation of PZC based 99m TC generator to be available for clinical application. Paper presented to the IAEA’s coordinated research project first research coordination meeting. "Development of generator technologies for therapeutic radionuclides." 4th-8th October 2004, Vienna, Austria.