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ANSTO Publications Online >
Journal Publications >
Journal Articles >
Please use this identifier to cite or link to this item:
http://apo.ansto.gov.au/dspace/handle/10238/3199
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| Title: | High-contrast PET of melanoma using F-18-MEL050, a selective probe for melanin with predominantly renal clearance. |
| Authors: | Denoyer, D Greguric, I Roselt, P Neels, OC Aide, N Taylor, SR Katsifis, A Dorow, DS Hicks, RJ |
| Keywords: | Neoplasms Melanin Renal Clearance Positron Computed Tomography Lungs Mice |
| Issue Date: | Mar-2010 |
| Publisher: | Society of Nuclear Medicine |
| Citation: | Denoyer, D., Greguric, I., Roselt, P., Neels, O. C., Aide, N., Taylor, S. R., et al. (2010). High-contrast PET of melanoma using F-18-MEL050, a selective probe for melanin with predominantly renal clearance. Journal of Nuclear Medicine, 51(3), 441-447. |
| Abstract: | The aim of this study was to evaluate the novel probe 18F-6-fluoro-N-[2-(diethylamino)ethyl] pyridine-3-carboxamide (18F-MEL050) for the imaging of primary and metastatic melanoma. Methods: PET using 18F-MEL050 was performed in murine models of melanoma. The specificity of 18F-MEL050 was studied by comparing its accumulation in pigmented B16-F0 allograft tumors with that of human amelanotic A375 xenografts using PET and high-resolution autoradiography. 18F-MEL050 PET results were compared with 18F-FDG PET, the current standard in melanoma molecular imaging. To test the ability of 18F-MEL050 to assess the metastatic spread of melanoma, a murine model of lung metastasis was imaged by PET/CT, and results correlated with physical assessment of tumor burden in the lungs. Results: In pigmented B16-F0 grafts, 18F-MEL050 PET yielded a tumor-to-background ratio of approximately 20:1 at 1 h and greater than 50:1 at 2 and 3 h. In the B16-F0 melanoma allograft model, tumor-to-background ratio was more than 9-fold higher for 18F-MEL050 than for 18F-FDG (50.9 ± 6.9 vs. 5.8 ± 0.5). No uptake was observed in the amelanotic melanoma xenografts. Intense uptake of 18F-MEL050 was evident in metastatic lesions in the lungs of B16-BL6 tumor–bearing mice on PET at 2 h after tracer injection, with high concordance between 18F-MEL050 accumulation on PET/CT and tumor burden determined at necroscopy. Conclusion: 18F-MEL050 has a rapid tumor uptake and high retention with specificity for melanin, suggesting great potential for noninvasive clinical evaluation of suspected metastatic melanoma. © 2010, Society of Nuclear Medicine |
| URI: | http://dx.doi.org/10.2967/jnumed.109.070060 http://apo.ansto.gov.au/dspace/handle/10238/3199 |
| ISSN: | 0161-5505 |
| Appears in Collections: | Journal Articles |
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