A rapid solid-phase extraction method for measurement of non-metabolised peripheral benzodiazepine receptor ligands, [18F]PBR102 and [18F]PBR111, in rat and primate plasma

To develop a rapid and reliable method for estimating non-metabolised PBR ligands fluoroethoxy ([18F]PBR102)- and fluoropropoxy ([18F]PBR111)-substituted 2-(6-chloro-2-phenyl)imidazo[1,2-a]pyridine-3-yl)-N,N-diethylacetamides in plasma. © 2011 Elsevier Inc.

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Metabolites, Plasma, Extraction, Animals, Rats, High-performance liquid chromatography

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Katsifis, A., Loc'h, C., Henderson, D., Bourdier, T., Pham, T., Greguric, I., Lam, P., Callaghan, P. D., Mattner, F., Eberl, S., & Fulham, M. (2011). A rapid solid-phase extraction method for measurement of non-metabolised peripheral benzodiazepine receptor ligands, [18F]PBR102 and [18F]PBR111, in rat and primate plasma. Nuclear Medicine and Biology, 38(1), 137-148. doi:10.1016/j.nucmedbio.2010.07.008

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http://dx.doi.org/10.1016/j.nucmedbio.2010.07.008
http://apo.ansto.gov.au/dspace/handle/10238/3100

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A rapid solid-phase extraction method for measurement of non-metabolised peripheral benzodiazepine receptor ligands, [18F]PBR102 and [18F]PBR111, in rat and primate plasma

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