Imaging cancer using PET - the effect of the bifunctional chelator on the biodistribution of a 64Cu-labeled antibody.

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Date
2011-01-01
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier
Abstract
Use of copper radioisotopes in antibody radiolabeling is challenged by reported loss of the radionuclide from the bifunctional chelator used to label the protein. The objective of this study was to investigate the relationship between the thermodynamic stability of the 64Cu-complexes of five commonly used bifunctional chelators (BFCs) and the biodistribution of an antibody labeled with 64Cu using these chelators in tumor-bearing mice. © 2011, Elsevier
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Keywords
Mice, Copper 64, Labelling, Thermodynamics, Radioisotopes, Neoplasms
Citation
Dearling, J. L. J., Voss, S. D., Dunning, P., Snay, E., Fahey, F., Smith, S. V., Huston, J. S., Meares, C. F., Treves, S. T., Packard, A. B. (2011). Imaging cancer using PET - the effect of the bifunctional chelator on the biodistribution of a 64Cu-labeled antibody. Nuclear Medicine and Biology, 38(1), 29-38. doi:10.1016/j.nucmedbio.2010.07.003
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