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Please use this identifier to cite or link to this item: http://apo.ansto.gov.au/dspace/handle/10238/3072

Title: Cerebral monoamine oxidase a inhibition in tobacco smokers confirmed with PET and [c-11]befloxatone.
Authors: Leroy, C
Bragulat, V
Berlin, I
Gregoire, MC
Bottlaender, M
Roumenov, D
Dolle, F
Bourgeois, S
Penttilae, J
Artiges, E
Martinot, JL
Trichard, C
Keywords: Tobacco Smokes
Positron Computed Tomography
Inhibition
Patients
Behavior
Amine Oxidases
Issue Date: Feb-2009
Publisher: Lippincott, Williams & Wilkins
Citation: Leroy, C., Bragulat, V., Berlin, I., Gregoire, M. C., Bottlaender, M., Roumenov, D., et al. (2009). Cerebral monoamine oxidase a inhibition in tobacco smokers confirmed with PET and [c-11]befloxatone. Journal of Clinical Psychopharmacology, 29(1), 86-88.
Abstract: The inhibition of cerebral monoamine oxidases (MAOs) by cigarette smoke components could participate to the tobacco addiction. However, the actual extent of this inhibition in vivo in smokers is still poorly known. We investigated cerebral MAO-A availability in 7 tobacco-dependent subjects and 6 healthy nonsmokers, using positron emission tomography (PET) and the MAO-A selective radioligand [11C]befloxatone. In comparison to nonsmokers, smokers showed a significant overall reduction of [11C]befloxatone binding potential (BP) in cortical areas (average reduction, -60%) and a similar trend in caudate and thalamus (-40%). Our findings confirm a widespread inhibition of cerebral MAO-A in smokers. This mechanism may contribute to tobacco addiction and for a possible mood-modulating effect of tobacco. © 2009, Lippincott, Williams & Wilkins
URI: http://dx.doi.org/10.1097/JCP.0b013e31819e98f
http://apo.ansto.gov.au/dspace/handle/10238/3072
ISSN: 0271-0749
Appears in Collections:Journal Articles

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