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Please use this identifier to cite or link to this item: http://apo.ansto.gov.au/dspace/handle/10238/3035

Title: Discovery of [F-18]N-(2-(Diethylamino)ethyl)-6-fluoronicotinamide: a melanoma positron emission tomography imaging radiotracer with high tumor to body contrast ratio and rapid renal clearance.
Authors: Greguric, I
Taylor, SR
Denoyer, D
Ballantyne, P
Berghofer, P
Roselt, P
Pham, TQ
Mattner, F
Bourdier, T
Neels, OC
Dorow, DS
Loc'h, C
Hicks, RJ
Katsifis, A
Keywords: Drugs
Neoplasms
Renal Clearance
Positron Computed Tomography
Nicotinamide
Clinical Trials
Issue Date: 10-Sep-2009
Publisher: American Chemical Society
Citation: Greguric, I., Taylor, S. R., Denoyer, D., Ballantyne, P., Berghofer, P., Roselt, P., et al. (2009). Discovery of [f-18]n-(2-(diethylamino)ethyl)-6-fluoronicotinamide: a melanoma positron emission tomography imaging radiotracer with high tumor to body contrast ratio and rapid renal clearance. Journal of Medicinal Chemistry, 52(17), 5299-5302.
Abstract: The high melanoma uptake and rapid body clearance displayed by our series of [123I]iodonicotinamides prompted the development of [18F]N-(2-(diethylamino)ethyl)-6-fluoronicotinamide ([18F]2), a novel radiotracer for PET melanoma imaging. Significantly, unlike fluorobenzoates, [18F]fluorine incorporation on the nicotinamide ring is one step, facile, and high yielding. [18F]2 displayed high tumor uptake, rapid body clearance via predominantly renal excretion, and is currently being evaluated in preclinical studies for progression into clinical trials to assess the responsiveness of therapeutic agents. © 2009, American Chemical Society
URI: http://dx.doi.org/10.1021/jm9008423
http://apo.ansto.gov.au/dspace/handle/10238/3035
ISSN: 0022-2623
Appears in Collections:Journal Articles

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