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Title: An investigation into the potential of SarAr for use in Cu-64 radioimmunotherapy.
Authors: Di Bartolo, N
Smith, SV
Hetherington, E
Sargeson, A
Keywords: Radioimmunotherapy
Iodine 123
Copper 64
Issue Date: 13-Oct-2009
Publisher: CSIRO Publishing
Citation: Di Bartolo, N., Smith, S. V., Hetherington, E., & Sargeson, A. (2009). An investigation into the potential of SarAr for use in Cu-64 radioimmunotherapy. Australian Journal of Chemistry, 62(10), 1261-1270.
Abstract: The B72.3 monoclonal antibody was radiolabelled with 123I, and with 111In and 64Cu, using DTPA and SarAr, respectively. Their biodistribution in tumour-bearing nude mice was used to calculate the dosimetry of their respective therapeutic analogue, using 131I, 90Y, 67Cu, and 64Cu. Two dosimetry models were used: one using the classical approach and a second model that takes into consideration the chemical stability of the radiolabelling methods employed and the biological clearance of each radioimmunoconjugate. Results clearly show that the 64Cu-SarAr-B72.3 could be used as a therapeutic agent and, theoretically, be at least as effective as any of the other therapeutic radionuclides currently studied, such as 131I, 90Y, and 67Cu. © 2009, CSIRO Publishing
ISSN: 0004-9425
Appears in Collections:Journal Articles

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