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Please use this identifier to cite or link to this item: http://apo.ansto.gov.au/dspace/handle/10238/2959

Title: Segmentation of small animal PET/CT mouse brain scans using an MRI-based 3D digital atlas: application in a neuroinflammation mouse model.
Authors: Delzescaux, T
Lebenberg, J
Raguet, H
Hantraye, P
Souedet, N
Gregoire, MC
Keywords: Rodents
Brain
Inflammation
Magnetic Resonance
Images
Positron Computed Tomography
Issue Date: 2-Sep-2010
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Citation: Delzescaux, T., Lebenberg, J., Raguet, T., Hantraye, P., Souedet, N., & Gregoire, M. C. (2010). Segmentation of small animal PET/CT mouse brain scans using an MRI-based 3D digital atlas: application in a neuroinflammation mouse model. 32nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC'10) - "Merging Medical Humanism and Technology", 31st August - 4th September 2010. In Proceedings of the 2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society (pp. 3097-3100, ThDPo06.5). Buenos Aires, Argentina: Buenos Aires Sheraton Hotel.
Abstract: The work reported in this paper aimed at developing and testing an automated method to calculate the biodistribution of a specific PET tracer in mouse brain PET/CT images using an MRI-based 3D digital atlas. Surface-based registration strategy and affine transformation estimation were considered. Such an approach allowed overcoming the lack of anatomical information in the inner regions of PET/CT brain scans. Promising results were obtained in one mouse (on two scans) and will be extended to a neuroinflammation mouse model to characterize the pathology and its evolution. Major improvements are expected regarding automation, time computation, robustness and reproducibility of mouse brain segmentation. Due to its generic implementation, this method could be successfully applied to PET/CT brain scans of other species (rat, primate) for which 3D digital atlases are available.
URI: http://dx.doi.org/10.1109/IEMBS.2010.5626106
http://apo.ansto.gov.au/dspace/handle/10238/2959
ISBN: 9781424441235
ISSN: 1557-170X
Appears in Collections:Conference Publications

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