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Please use this identifier to cite or link to this item: http://apo.ansto.gov.au/dspace/handle/10238/2710

Title: Experimental validation of proton transverse relaxivity models for superparamagnetic nanoparticle MRI contrast agents.
Authors: Carroll, MRJ
Woodward, RC
House, MJ
Teoh, WY
Amal, R
Hanley, TL
St Pierre, TG
Keywords: Magnetic Resonance
Transverse Momentum
Relaxation
Iron Oxides
Protons
NMR Imaging
Issue Date: 22-Jan-2010
Publisher: Institute of Physics
Citation: Carroll, M. R. J., Woodward, R. C., House, M. J., Teoh, W. Y., Amal, R., & Hanley, T. L., et al. (2010). Experimental validation of proton transverse relaxivity models for superparamagnetic nanoparticle MRI contrast agents. Nanotechnology, 21(3), 7.
Abstract: Analytical models of proton transverse relaxation rate enhancement by magnetic nanoparticles were tested by making measurements on model experimental systems in a field of 1.4 T. Proton relaxivities were measured for five aqueous suspensions of iron oxide (maghemite) nanoparticles with nominal mean particle sizes of 6, 8, 10, 11, and 13 nm. Proton relaxivity increased with mean particle size ranging from 13 s(-1) mM Fe-1 for the 6 nm sample, up to 254 s(-1) mM Fe-1 for the 13 nm sample. A strong correlation between the measured and predicted values of the relaxivity was observed, with the predicted values being consistently higher than the measured values. The results indicate that the models give a reasonable agreement with experimental results and hence can be used as the basis for the design of new magnetic resonance imaging contrast and labelling agents. © 2010, Institute of Physics
URI: http://dx.doi.org/10.1088/0957-4484/21/3/035103
http://apo.ansto.gov.au/dspace/handle/10238/2710
ISSN: 0957-4484
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