ANSTO Publications Online >
Journal Publications >
Journal Articles >

Please use this identifier to cite or link to this item: http://apo.ansto.gov.au/dspace/handle/10238/1851

Title: PAMAM dendrimers as potential agents against fibrillation of α-synuclein, a parkinson's disease-related protein.
Authors: Rekas, A
Lo, V
Gadd, GE
Cappai, R
Yun, SL
Keywords: Small Angle Scattering
Agglomeration
Peptides
Fluorescence
Amorphous State
Transmission Electron Microscopy
Issue Date: 10-Mar-2009
Publisher: Wiley-VCH Verlag Berlin
Citation: Rekas, A., Lo, V., Gadd, G. E., Cappai, R., & Yun, S. L. (2009). PAMAM dendrimers as potential agents against fibrillation of α-synuclein, a parkinson's disease-related protein. Macromolecular Bioscience, 9(3), 230-238.
Abstract: The effect of PAMAM dendrimers (generations G3, G4 and G5) on the fibrillation of α-synuclein was examined by fluorescence and CD spectroscopy, TEM and SANS. PAMAM dendrimers inhibited fibrillation of α-synuclein and this effect increased both with generation number and PAMAM concentration. SANS showed structural changes in the formed aggregates of α-synuclein - from cylindrical to dense three-dimensional ones-as the PAMAM concentration increased, on account of the inhibitory effect. PAMAM also effectively promoted the breaking down of pre-existing fibrils of α-synuclein. In both processes-that is, inhibition and disassociation of fibrils-PAMAM redirected α-synuclein to an amorphous aggregation pathway. © 2009, Wiley-VCH Verlag Berlin
URI: http://dx.doi.org/10.1002/mabi.200800242
http://apo.ansto.gov.au/dspace/handle/10238/1851
ISSN: 1616-5187
Appears in Collections:Journal Articles

Files in This Item:

There are no files associated with this item.

Items in APO are protected by copyright, with all rights reserved, unless otherwise indicated.

 

Valid XHTML 1.0! DSpace Software Copyright © 2002-2010  Duraspace - Feedback