ANSTO Publications Online >
Journal Publications >
Journal Articles >

Please use this identifier to cite or link to this item: http://apo.ansto.gov.au/dspace/handle/10238/1721

Title: Effect of temperature during assembly on the structure and mechanical properties of peptide-based materials.
Authors: Ramachandran, S
Taraban, MB
Trewhella, J
Gryczynski, I
Gryczynski, Z
Yu, YB
Keywords: Hydrogels
Peptides
Temperature Range
Mechanical Properties
Small Angle Scattering
Fluorescence Spectroscopy
Issue Date: 1-Jun-2010
Publisher: American Chemical Society
Citation: Ramachandran, S., Taraban, M. B., Trewhella, J., Gryczynski, I., Gryczynski, Z., & Yu, Y. B. (2010). Effect of temperature during assembly on the structure and mechanical properties of peptide-based materials. Biomacromolecules, 11(6), 1502-1506.
Abstract: Mutually complementary, self-repulsive oligopeptide pairs were designed to coassemble into viscoelastic hydrogels. Peptide engineering was combined with biophysical techniques to investigate the effects of temperature on the structural and mechanical properties of the resulting hydrogels. Biophysical characterizations, including dynamic rheometry, small-angle X-ray scattering (SAXS), and fluorescence spectroscopy, were used to investigate hydrogelation at the bulk, fiber, and molecular levels, respectively. It has been found that temperature has a significant effect on the structure and mechanical properties of peptide-based biomaterials. Oligopeptide fibers assembled at 25°C are formed faster and are two times thicker, and the resulting material is mechanically seven times stronger than that assembled at 5°C. © 2010, American Chemical Society
URI: http://dx.doi.org/10.1021/bm100138m
http://apo.ansto.gov.au/dspace/handle/10238/1721
ISSN: 1525-7797
Appears in Collections:Journal Articles

Files in This Item:

There are no files associated with this item.

Items in APO are protected by copyright, with all rights reserved, unless otherwise indicated.

 

Valid XHTML 1.0! DSpace Software Copyright © 2002-2010  Duraspace - Feedback