A new N-terminal protecting group for peptide attachment to insoluble supports.

Abstract

Cobalt(III) active ester complexes [Co(en)2(NH2CHRCOOR')]-(CIOO3, where en is ethylenediamine, R is H or -CH2- and R1 is CH3, C2H5 or C3H7 , have been used to provide N-terminal protection before the attachment of peptides to insoluble polymeric supports. The protecting group can be removed readily and quantitatively using normal physiological parameters from peptides attached to non-crosslinked resins.