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https://apo.ansto.gov.au/dspace/handle/10238/9236| Title: | Synthesis of 1,4-triazole linked zanamivir dimers as highly potent inhibitors of influenza A and B |
| Authors: | Fraser, BH Hamilton, S Krause-Heuer, AM Wright, PJ Greguric, I Tucker, SP Draffan, AG Fokin, VV Sharpless, KB |
| Keywords: | Synthesis Triazoles Dimers Influenza Enzyme inhibitors Viruses Lungs Tissues |
| Issue Date: | 29-Nov-2012 |
| Publisher: | The Royal Society of Chemistry |
| Citation: | Fraser, B. H., Hamilton, S., Krause-Heuer, A. M., Wright, P. J., Greguric, I., Tucker, S. P., Draffan, A. G., Fokin, V. V., & Sharpless, K. B. (2013). Synthesis of 1, 4-triazole linked zanamivir dimers as highly potent inhibitors of influenza A and B. RSC Mediconal Chemistry, 4(2), 383-386. doi.10.1039/C2MD20300F |
| Abstract: | The copper catalyzed azide alkyne cycloaddition (CuAAC) reaction – the quintessential ‘click’ reaction – was used to synthesise dimers of the neuraminidase inhibitor zanamivir in high yields. The effect upon anti-viral activity of varying the linker length and the number of triazole units was explored. All dimers were tested for anti-viral activity against influenza A/Sydney/5/97 and B/Harbin/7/94 in a cytopathic effect (CPE) assay. © Royal Society of Chemistry |
| Gov't Doc #: | 8754 |
| URI: | https://doi.org/10.1039/C2MD20300F http://apo.ansto.gov.au/dspace/handle/10238/9236 |
| ISSN: | 2632-8682 |
| Appears in Collections: | Journal Articles |
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