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Title: Synthesis and stability of S-(2-[18F]fluoroethyl)-L-homocysteine for potential tumour imaging
Authors: Bourdier, T
Fookes, CJR
Pham, TQ
Greguric, I
Katsifis, A
Keywords: Synthesis
Hydroxyl radicals
Issue Date: 25-Sep-2008
Publisher: John Wiley and Sons
Citation: Bourdier, T., Fookes, C. J. R., Pham, T. Q., Greguric, I., & Katsifis, A. (2008). Synthesis and stability of S‐(2‐[18F] fluoroethyl)‐L‐homocysteine for potential tumour imaging. Journal of Labelled Compounds and Radiopharmaceuticals, 51(11), 369-373. doi:10.1002/jlcr.1539
Abstract: inThe F-18 labelled methionine derivative S-(2-[18F]fluoroethyl)-L-homocysteine ([18F]FEHCys) was prepared by a one-pot two-step synthesis via the protected S-(2-bromoethyl)-L-homocysteine 1 and S-(2-chloroethyl)-L-homocysteine 2 precursors. The bromoethyl derivative 1 gave higher radiochemical yields (40% at 5 min) at 100°C compared with the chloro-analogue (22% at 100°C in 30 min). However, [18F]FEHCys was found to be unstable in aqueous systems being transformed to the corresponding hydroxyl derivative within 20 min. © 2008 John Wiley & Sons, Ltd.
Gov't Doc #: 8682
ISSN: 1099-1344
Appears in Collections:Journal Articles

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