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|Title:||Synthesis and stability of S-(2-[18F]fluoroethyl)-L-homocysteine for potential tumour imaging|
|Publisher:||John Wiley and Sons|
|Citation:||Bourdier, T., Fookes, C. J. R., Pham, T. Q., Greguric, I., & Katsifis, A. (2008). Synthesis and stability of S‐(2‐[18F] fluoroethyl)‐L‐homocysteine for potential tumour imaging. Journal of Labelled Compounds and Radiopharmaceuticals, 51(11), 369-373. doi:10.1002/jlcr.1539|
|Abstract:||inThe F-18 labelled methionine derivative S-(2-[18F]fluoroethyl)-L-homocysteine ([18F]FEHCys) was prepared by a one-pot two-step synthesis via the protected S-(2-bromoethyl)-L-homocysteine 1 and S-(2-chloroethyl)-L-homocysteine 2 precursors. The bromoethyl derivative 1 gave higher radiochemical yields (40% at 5 min) at 100°C compared with the chloro-analogue (22% at 100°C in 30 min). However, [18F]FEHCys was found to be unstable in aqueous systems being transformed to the corresponding hydroxyl derivative within 20 min. © 2008 John Wiley & Sons, Ltd.|
|Gov't Doc #:||8682|
|Appears in Collections:||Journal Articles|
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