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dc.contributor.authorArima, V-
dc.contributor.authorPascali, G-
dc.contributor.authorLade, O-
dc.contributor.authorKretschmer, HR-
dc.contributor.authorBernsdorf, I-
dc.contributor.authorHammond, V-
dc.contributor.authorWatts, P-
dc.contributor.authorDe Leonardis, F-
dc.contributor.authorTarn, MD-
dc.contributor.authorPamme, N-
dc.contributor.authorCvetkovic, BJ-
dc.contributor.authorDitrrich, PS-
dc.contributor.authorVasovic, N-
dc.contributor.authorDuane, R-
dc.contributor.authorJaksic, A-
dc.contributor.authorZacheo, A-
dc.contributor.authorZizzari, A-
dc.contributor.authorMarra, L-
dc.contributor.authorPerrone, E-
dc.contributor.authorSalvadori, PA-
dc.contributor.authorRinaldi, R-
dc.identifier.citationArima, V., Pascali, G., Lade, O., Kretschmer, H. R., Bernsdorf, I., Hammond, V.,Watts, P., De Leonardis, F., Tarn, M. D., Pamme, N., Cvetkovic, B.J., Dittrich, P. S., Vasovic, N., Duane., R., Jaksic, A., Zacheo, A., Zizzari, A., Marra, L., Perrone, E., Salvadori, P. A., & Rinaldi, R. (2013). Radiochemistry on chip: towards dose-on-demand synthesis of PET radiopharmaceuticals. Lab on a Chip, 13(12), 2328-2336. doi:10.1039/C3LC00055Aen_AU
dc.description.abstractAbstractWe have developed an integrated microfluidic platform for producing 2-[18F]-fluoro-2-deoxy-D-glucose (18F-FDG) in continuous flow from a single bolus of radioactive isotope solution, with constant product yields achieved throughout the operation that were comparable to those reported for commercially available vessel-based synthesisers (40–80%). The system would allow researchers to obtain radiopharmaceuticals in a dose-on-demand setting within a few minutes. The flexible architecture of the platform, based on a modular design, can potentially be applied to the synthesis of other radiotracers that require a two-step synthetic approach, and may be adaptable to more complex synthetic routes by implementing additional modules. It can therefore be employed for standard synthesis protocols as well as for research and development of new radiopharmaceuticals. © 2013 The Royal Society of Chemistryen_AU
dc.publisherThe Royal Society of Chemistryen_AU
dc.subjectPositron computed tomographyen_AU
dc.subjectLabelled compoundsen_AU
dc.titleRadiochemistry on chip: towards dose-on-demand synthesis of PET radiopharmaceuticalsen_AU
dc.typeJournal Articleen_AU
Appears in Collections:Journal Articles

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