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https://apo.ansto.gov.au/dspace/handle/10238/9138| Title: | Radiochemistry on chip: towards dose-on-demand synthesis of PET radiopharmaceuticals |
| Authors: | Arima, V Pascali, G Lade, O Kretschmer, HR Bernsdorf, I Hammond, V Watts, P De Leonardis, F Tarn, MD Pamme, N Cvetkovic, BJ Ditrrich, PS Vasovic, N Duane, R Jaksic, A Zacheo, A Zizzari, A Marra, L Perrone, E Salvadori, PA Rinaldi, R |
| Keywords: | Positron computed tomography Radiopharmaceuticals Synthesis Fluorodeoxyglucose Glucose Labelled compounds |
| Issue Date: | 25-Mar-2013 |
| Publisher: | The Royal Society of Chemistry |
| Citation: | Arima, V., Pascali, G., Lade, O., Kretschmer, H. R., Bernsdorf, I., Hammond, V.,Watts, P., De Leonardis, F., Tarn, M. D., Pamme, N., Cvetkovic, B.J., Dittrich, P. S., Vasovic, N., Duane., R., Jaksic, A., Zacheo, A., Zizzari, A., Marra, L., Perrone, E., Salvadori, P. A., & Rinaldi, R. (2013). Radiochemistry on chip: towards dose-on-demand synthesis of PET radiopharmaceuticals. Lab on a Chip, 13(12), 2328-2336. doi:10.1039/C3LC00055A |
| Abstract: | AbstractWe have developed an integrated microfluidic platform for producing 2-[18F]-fluoro-2-deoxy-D-glucose (18F-FDG) in continuous flow from a single bolus of radioactive isotope solution, with constant product yields achieved throughout the operation that were comparable to those reported for commercially available vessel-based synthesisers (40–80%). The system would allow researchers to obtain radiopharmaceuticals in a dose-on-demand setting within a few minutes. The flexible architecture of the platform, based on a modular design, can potentially be applied to the synthesis of other radiotracers that require a two-step synthetic approach, and may be adaptable to more complex synthetic routes by implementing additional modules. It can therefore be employed for standard synthesis protocols as well as for research and development of new radiopharmaceuticals. © 2013 The Royal Society of Chemistry |
| Gov't Doc #: | 8664 |
| URI: | http://doi.org/10.1039/C3LC00055A http://apo.ansto.gov.au/dspace/handle/10238/9138 |
| ISSN: | 1473-0197 |
| Appears in Collections: | Journal Articles |
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