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Title: Investigating the cytotoxicity of platinum(II) complexes incorporating bidentate pyridyl-1,2,3-triazole “click” ligands
Authors: Pages, BJ
Sakoff, J
Gilbert, J
Zhang, Y
Li, F
Preston, D
Crowley, JD
Aldrich-Wright, JR
Keywords: Platinum
Crystal structure
Nuclear magnetic resonance
In vitro
X-ray diffraction
Issue Date: 1-Dec-2016
Publisher: Elsevier B.V.
Citation: Pages, B. J., Sakoff, J., Gilbert, J., Zhang, Y., Li, F., Preston, D., Cowley, J. D., & Aldrich-Wright, J. R. (2016). Investigating the cytotoxicity of platinum (II) complexes incorporating bidentate pyridyl-1, 2, 3-triazole “click” ligands. Journal of Inorganic Biochemistry, 165, 92-99. doi:10.1016/j.jinorgbio.2016.06.017
Abstract: Six platinum(II) complexes of the type [Pt(PL)(AL)]2 +, where PL is a bidentate pyridyl-1,2,3-triazole “click” ligand and AL is the R,R or S,S isomer of 1.2-diaminocyclohexane, have been synthesised and characterised by several methods including elemental microanalysis, proton NMR spectroscopy and X-ray crystallography. The in vitro cytotoxicity of each complex was assessed in eleven cell lines, revealing moderate to good activity for complexes incorporating 2-(1-phenyl-1H-1,2,3-triazol-4-yl)pyridine. © 2016 Elsevier B.V.
Gov't Doc #: 9012
ISSN: 0162-0134
Appears in Collections:Journal Articles

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