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|Title:||Rhenium and technetium tricarbonyl complexes of N-Heterocyclic carbene ligands|
|Publisher:||American Chemical Society|
|Citation:||Chan, C. Y., Pellegrini, P. A., Greguric, I., & Barnard, P. J. (2014). Rhenium and technetium tricarbonyl complexes of N-heterocyclic carbene ligands. Inorganic chemistry, 53(20), 10862-10873. doi:10.1021/ic500917s|
|Abstract:||A strategy for the conjugation of N-heterocyclic carbene (NHC) ligands to biomolecules via amide bond formation is described. Both 1-(2-pyridyl)imidazolium or 1-(2-pyridyl)benzimidazolium salts functionalized with a pendant carboxylic acid group were prepared and coupled to glycine benzyl ester using 1-ethyl-3-(3-(dimethylamino)propyl)carbodiimide. A series of 10 rhenium(I) tricarbonyl complexes of the form [ReX(CO)3(ĈN)] (ĈN is a bidentate NHC ligand, and X is a monodentate anionic ligand: Cl–, RCO2–) were synthesized via a Ag2O transmetalation protocol from the Re(I) precursor compound Re(CO)5Cl. The synthesized azolium salts and Re(I) complexes were characterized by elemental analysis and by 1H and 13C NMR spectroscopy, and the molecular structures for one imidazolium salt and seven Re(I) complexes were determined by single-crystal X-ray diffraction. 1H NMR and mass spectrometry studies for an acetonitrile-d3 solution of [ReCl(CO)3(1-(2-pyridyl)-3-methylimidazolylidene)] show that the monodentate chloride ligand is labile and exchanges with this solvent yielding a cationic acetonitrile adduct. For the first time the labeling of an NHC ligand with technetium-99m is reported. Rapid Tc-99m labeling was achieved by heating the imidazolium salt 1-(2-pyridyl)-3-methylimidazolium iodide and Ag2O in methanol, followed by the addition of fac-[99mTc(OH2)3(CO)3]+. To confirm the structure of the 99mTc-labeled complex, the equivalent 99Tc complex was prepared, and mass spectrometric studies showed that the formed Tc complexes are of the form [99m/99Tc(CH3CN)(CO)3(1-(2-pyridyl)-3-methylimidazolylidene)]+ with an acetonitrile molecule coordinated to the metal center. © 2014 American Chemical Society|
|Gov't Doc #:||8695|
|Appears in Collections:||Journal Articles|
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