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Title: An16-resilin: An advanced multi-stimuli-responsive resilin-mimetic protein polymer
Authors: Rajkamal, B
Dutta, NK
Choudhury, NR
Elvin, CM
Lyon, RE
Knott, RB
Hill, AJ
Keywords: Proteins
Genetic engineering
Amino acids
Issue Date: 1-Nov-2014
Publisher: Elsevier
Citation: Balu, R., Dutta, N. K., Choudhury, N. R., Elvin, C. M., Lyons, R. E., Knott, R., & Hill, A. J. (2014). An16-resilin: An advanced multi-stimuli-responsive resilin-mimetic protein polymer. Acta Biomaterialia, 10(11), 4768-4777. doi:10.1016/j.actbio.2014.07.030
Abstract: Engineered protein polymers that display responsiveness to multiple stimuli are emerging as a promising class of soft material with unprecedented functionality. The remarkable advancement in genetic engineering and biosynthesis has created the opportunity for precise control over the amino acid sequence, size, structure and resulting functions of such biomimetic proteins. Herein, we describe the multi-stimuli-responsive characteristics of a resilin-mimetic protein, An16-resilin (An16), derived from the consensus sequence of resilin gene in the mosquito Anopheles gambiae. We demonstrate that An16 is an intrinsically disordered protein that displays unusual dual-phase thermal transition behavior along with responsiveness to pH, ion, light and humidity. Identifying the molecular mechanisms that allow An16 to sense and switch in response to varying environments furthers the ability to design intelligent biomacromolecules. © 2014 Acta Materialia Inc.
Gov't Doc #: 6523
ISSN: 1742-7061
Appears in Collections:Journal Articles

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