Please use this identifier to cite or link to this item: https://apo.ansto.gov.au/dspace/handle/10238/6121
Title: Insulin decreases therapeutic efficacy in colon cancer cell line HT29 via the activation of the PI3K/Akt pathway.
Authors: Chen, J
Katsifis, A
Hu, C
Huang, XF
Keywords: Insulin
Cycloheximide
Metabolic diseases
Fluorouracils
Chemotherapy
Large intestine
Neoplasms
Carcinogenesis
Issue Date: 1-Jun-2011
Publisher: Bentham Science Publishers Ltd
Citation: Chen, J., Katsifis, A., Hu, C., & Huang, X-F (2011). Insulin decreases therapeutic efficacy in colon cancer cell line HT29 via the activation of the PI3K/Akt pathway. Current Drug Discovery Technologies, 8(2), 119-25. doi:10.2174/157016311795563820
Abstract: Obesity has been associated with both the carcinogenesis and poor prognosis of colon cancer, one of the leading causes of cancer-related death. Increased blood levels of insulin in obese subjects have been demonstrated to play a key role in carcinogenesis. It is also possible that insulin affects treatment efficacy, leading to poor prognosis. In this study, we demonstrated that insulin can increase HT29 colon cancer cell line resistance to cycloheximide and 5- fluorouracil induced cytotoxicity. This effect can be inhibited by the PI3K/Akt inhibitor Ly294002, indicating the important role of this pathway in the insulin-induced inefficacy of chemotherapy. The insulin-induced resistance to cycloheximide and 5-fluorouracil can be used in drug screening to overcome the inefficacy of chemotherapy in obesity-associated colon cancer. © 2011 Bentham Science Publishers
Gov't Doc #: 5281
URI: http://dx.doi.org/10.2174/157016311795563820
http://apo.ansto.gov.au/dspace/handle/10238/6121
ISSN: 1570-1638
Appears in Collections:Journal Articles

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.