Please use this identifier to cite or link to this item: https://apo.ansto.gov.au/dspace/handle/10238/5938
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dc.contributor.authorBottlaender, MA-
dc.contributor.authorValette, H-
dc.contributor.authorDelforge, J-
dc.contributor.authorSaba, W-
dc.contributor.authorGuenther, I-
dc.contributor.authorCuret, O-
dc.contributor.authorGeorge, P-
dc.contributor.authorDollé, F-
dc.contributor.authorGregoire, MC-
dc.date.accessioned2014-10-20T23:46:47Z-
dc.date.available2014-10-20T23:46:47Z-
dc.date.issued2010-04-01-
dc.identifier.citationBottlaender, M., Valette, H., Delforge, J., Saba, W., Guenther, I., Curet, O., George, P., Dollé, F., & Gregoire, M. C. (2010). In vivo quantification of monoamine oxidase A in baboon brain: a PET study using [C-11]befloxatone and the multi-injection approach. Journal of Cerebral Blood Flow and Metabolism, 30(4), 792-800. doi:10.1038/jcbfm.2009.242en_AU
dc.identifier.govdoc5690-
dc.identifier.issn0271-678X-
dc.identifier.urihttp://dx.doi.org/10.1038/jcbfm.2009.242en_AU
dc.identifier.urihttp://apo.ansto.gov.au/dspace/handle/10238/5938-
dc.description.abstract[C-11]befloxatone is a high-affinity, reversible, and selective radioligand for the in vivo visualization of the monoamine oxidase A (MAO-A) binding sites using positron emission tomography (PET). The multi-injection approach was used to study in baboons the interactions between the MAO-A binding sites and [C-11] befloxatone. The model included four compartments and seven parameters. The arterial plasma concentration, corrected for metabolites, was used as input function. The experimental protocol-three injections of labeled and/or unlabeled befloxatone-allowed the evaluation of all the model parameters from a single PET experiment. In particular, the brain regional concentrations of the MAO-A binding sites (B-max(')) and the apparent in vivo befloxatone affinity (K-d) were estimated in vivo for the first time. A high binding site density was found in almost all the brain structures (170 +/- 39 and 194 +/- 26 pmol/mL in the frontal cortex and striata, respectively, n = 5). The cerebellum presented the lowest binding site density (66 +/- 13 pmol/mL). Apparent affinity was found to be similar in all structures (KdVR = 6.4 +/- 1.5 nmol/L). This study is the first PET-based estimation of the B-max of an enzyme. © 2010, Nature Publishing Group.en_AU
dc.language.isoenen_AU
dc.publisherNature Publishing Groupen_AU
dc.subjectBaboonsen_AU
dc.subjectMonkeysen_AU
dc.subjectPrimatesen_AU
dc.subjectMammalsen_AU
dc.subjectIn vivoen_AU
dc.subjectPositron computed tomographyen_AU
dc.subjectDopamineen_AU
dc.subjectAminesen_AU
dc.subjectTobaccoen_AU
dc.titleIn vivo quantification of monoamine oxidase A in baboon brain: a PET study using [C-11]befloxatone and the multi-injection approach.en_AU
dc.typeJournal Articleen_AU
dc.date.statistics2014-10-21-
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