Please use this identifier to cite or link to this item: https://apo.ansto.gov.au/dspace/handle/10238/4899
Title: Synthesis of cephalosporin-3'-diazeniumdiolates: biofilm dispersing NO-donor prodrugs activated by b-lactamase
Authors: Yepuri, NR
Barraud, N
Mohammadi, NS
Kardak, BG
Kjelleberg, S
Rice, SA
Kelso, MJ
Keywords: Nitric oxide
Isomerization
Chemistry
Dispersions
Antibodies
Drugs
Issue Date: 1-Jan-2013
Publisher: Royal Society of Chemistry
Citation: Yepuri, N. R., Barraud, N., Mohammadi, N. S., Kardak, B. G., Kjelleberg, S., Rice, S. A., & Kelso, M. J. (2013). Synthesis of cephalosporin-3'-diazeniumdiolates: biofilm dispersing NO-donor prodrugs activated by b-lactamase. Chemical Communications, 49 (42), 4791-4793. doi:10.1039/c3cc40869h
Abstract: Use of biofilm dispersing NO-donor compounds in combination with antibiotics has emerged as a promising new strategy for treating drug-resistant bacterial biofilm infections. This paper details the synthesis and preliminary evaluation of six cephalosporin-3[prime or minute]-diazeniumdiolates as biofilm-targeted NO-donor prodrugs. Each of the compounds is shown to selectively release NO following reaction with the bacteria-specific enzyme [small beta]-lactamase and to trigger dispersion of Pseudomonas aeruginosa biofilms in vitro. © 2013, Royal Society of Chemistry
Gov't Doc #: 5123
URI: http://dx.doi.org/10.1039/c3cc40869h
http://apo.ansto.gov.au/dspace/handle/10238/4899
ISSN: 1359-7345
Appears in Collections:Journal Articles

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.