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dc.contributor.authorDaly, HL-
dc.contributor.authorHall, MD-
dc.contributor.authorFailes, TW-
dc.contributor.authorZhang, M-
dc.contributor.authorForan, GJ-
dc.contributor.authorHambley, TW-
dc.identifier.citationDaly, H. L., Hall, M. D., Failes, T. W., Zhang, M., Foran, G. J., & Hambley, T. W. (2011). Stabilization of triam(m)inechloridoplatinum complexes by oxidation to PtIV. Australian Journal of Chemistry, 64(3), 273-278. doi:10.1071/CH11041en_AU
dc.description.abstractPtIV analogues of the active end groups {PtClN3} of multinuclear Pt anticancer drugs have been investigated. The crystal structure of trans,mer-[PtCl(OH)2(dien)]Cl shows that the bond lengths are similar to those in the dihydroxidoplatinum(iv) analogue of cisplatin. The axial ligands are shown to be the predominant influence on reduction potentials with the dihydroxido complex trans,mer-[PtCl(OH)2(NH3)3]Cl being the most resistant to reduction. X-ray absorption near-edge spectroscopy is shown to be suitable for monitoring the oxidation state of these complexes and reveals that trans,mer-[PtCl(OH)2(NH3)3]+ survives for more than 2 h in cancer cells. © 2011, CSIRO Publishingen_AU
dc.publisherCSIRO Publishingen_AU
dc.subjectCrystal structureen_AU
dc.subjectAbsorption spectroscopyen_AU
dc.titleStabilization of triam(m)inechloridoplatinum complexes by oxidation to PtIV.en_AU
dc.typeJournal Articleen_AU
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