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dc.contributor.authorKlenner, MA-
dc.contributor.authorZhang, B-
dc.contributor.authorCiancaleoni, G-
dc.contributor.authorHoward, JK-
dc.contributor.authorMaynard-Casely, HE-
dc.contributor.authorClegg, JK-
dc.contributor.authorMassi, M-
dc.contributor.authorFraser, BH-
dc.contributor.authorPascali, G-
dc.identifier.citationKlenner, M. A., Zhang, B., Ciancaleoni, G., Howard, J. K., Maynard-Casely, H. E., Clegg, J. K., Massi, M., Fraser, B. H. & Pascali, G. (2020). Rhenium (I) complexation–dissociation strategy for synthesising fluorine-18 labelled pyridine bidentate radiotracers. RSC Advances, 10(15), 8853-8865. doi:10.1039/D0RA00318Ben_US
dc.descriptionThis article is licensed under a Creative Commons Attribution Non-Commercial 3.0 Licence.en_US
dc.description.abstractA novel fluorine-18 method employing rhenium(I) mediation is described herein. The method was found to afford moderate to high radiochemical yields of labelled rhenium(I) complexes. Subsequent thermal dissociation of the complexes enabled the radiosynthesis of fluorine-18 labelled pyridine bidentate structures which could not be radiofluorinated hitherto. This rhenium(I) complexation–dissociation strategy was further applied to the radiosynthesis of [18F]CABS13, an Alzheimer's disease imaging agent, alongside other 2,2′-bipyridine, 1,10-phenanthroline and 8-hydroxyquinoline labelled radiotracers. Computational modelling of the reaction mechanism suggests that the efficiency of rhenium(I) activation may be attributed to both an electron withdrawal effect by the metal center and the formation of an acyl fluoride intermediate which anchors the fluoride subsequent to nucleophilic addition. © The Royal Society of Chemistry 2020 - Open Accessen_US
dc.publisherRoyal Society of Chemistryen_US
dc.subjectFluorine 18en_US
dc.subjectTracer techniquesen_US
dc.titleRhenium(i) complexation–dissociation strategy for synthesising fluorine-18 labelled pyridine bidentate radiotracersen_US
dc.typeJournal Articleen_US
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