Browsing by Author "van Heel, AJ"

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    Protein surface and core dynamics show concerted hydration-dependent activation
    (Wiley-V C H Verlag GMBH, 2013-01-01) Wood, K; Gallat, FX; Otten, R; van Heel, AJ; Lethier, M; van Eijck, L; Moulin, M; Haertlein, M; Weik, M; Mulder, FAA
    By specifically labeling leucine/valine methyl groups and lysine side chains “inside” and “outside” dynamics of proteins on the nanosecond timescale are compared using neutron scattering (see picture). Surprisingly, both groups display similar dynamics as a function of temperature, and the buried hydrophobic core is sensitive to hydration and undergoes a dynamical transition. © 2013, Wiley-VCH Verlag GmbH & Co. KGaA