Browsing by Author "Wilson, JG"

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    Recent radiopharmaceutical research at the AAEC Research Establishment
    (Australian Atomic Energy Commission, 1985-12) Wilson, JG; Boyd, RE
    During the past few years a large part of the radiochemical research carried out at Lucas Heights has been devoted to the synthesis of ligands capable of forming chelate complexes with technetium-99m as part of a search for tumour-localising radiopharmaceuticals. An account is given of the synthesis and biological evaluation of a range of these compounds and of the investigation of certain biochemical and biological properties affecting the clinical application of both ligands and radiopharmaceuticals. In addition to the search for novel Tc-99m radiopharmaceuticals major research programs on the development of Tc-99m generating systems have been in progress at Lucas Heights for several years. Work on the AAEC's Mark III Tc-99m technetium generator has been brought to a successful conclusion. A new type of Tc-99m generator which uses an insoluble zirconium molybdate gel and provides high yields of pertechnetate by a simple elution technique has also been developed. Studies are in progress on the osmium-iridium generator.