Browsing by Author "Tucker, AD"

Now showing 1 - 4 of 4
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    Haemolytic activity of uranium compounds: haemolysis by thermochemical derivatives of ammonium uranate.
    (Australian Atomic Energy Commission, 1975-01) Stuart, WI; Tucker, AD; Adams, RB; Smith, HE
    A study has been made of the haemolytic action on human erythrocytes by ammonium uranate (AU) and various thermochemical products of AU. These products were obtained by heating AU in hydrogen at 5ºC min-1 to various temperatures. Haemolysis has been interpreted in terms of a diffusion model which for each product yields a single parameter Kn, the haemolytic activity factor. The magnitude of Kn is a convenient measure of the ability of a powder to damage erythrocytes. The haemolytic activity of certain thermochemical derivatives indicates an exceptionally high potential for damage to erythrocytes. Infrared and thermoanalytical measurements have shown that the high activity of these products derives principally from a self-reduction reaction, induced by heating AU to 400-420ºC in hydrogen.
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    MED-records: an add database of AAEC medical records since 1966
    (Australian Atomic Engery Commission, 1986-08) Barry, JM; Pollard, JP; Tucker, AD
    Since its inception in 1958 most of the staff of the AAEC Research Establishment at Lucas Heights have had annual medical examinations. Medical information accrued since 1966 has been collected as an ADD database to allow ad hoc enquiries to be made against the data. Details are given of the database schema and numerous support routines ranging from the integrity checking of input data to analysis and plotting of the summary results.
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    Synergic factors in murine nephrosis, demonstrated by computer techniques
    (Australian Atomic Energy Commission, 1975-07) Tucker, AD; Ehmen, G; Smith, HE; Barry, JM; Bills, JW
    Simple environmental changes, including a whole, fresh diet, delayed the onset of the usual diseases of lungs and kidneys in laboratory rats. 'Spontaneous' nephrosis appears to develop from interactions involving inherent immune status, nurture, and environmental 'triggers', particularly inhalants. These methods could be adapted to toxicological investigations and the results suggest the need for new approaches in statistical and interpretative analyses.
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    Vascular injury in lung disease
    (Australian Atomic Energy Commission, 1975) Tucker, AD; Wyatt, JH; Barry, JM; Undery, D
    Inhaled particulates which stimulate a 'delayed', cellular mode of alveolar clearance are excreted to the airways through lymphoid foci in the bronchial bifurcations. The anatomic relations and developing pathology of the tissues adjacent to these foci, including the divisions of accompanying arteries, were studied by serial sectioning and photo-micrographic modelling of rat lungs. The changes are typical of classic 'delayed' inflammatory reactions and, in the rat, the fully developed stage is characterised by fibrinoid necrosis involving all three layers of the arterial wall in a linear lesion across the leading edge of the flow divider. An hypothesis was developed to relate the injury to pulsatile forces. Recent published findings indicate that similarly placed lesions, with species-specific changes in development, are universal in both cerebral and extra-cranial arterial forks of man and animals. Possible associations of the microvascular changes with human atherosclerosis and their further significance in pulmonary and systemic effects arising from industrial and environmental contaminants are explored.