Browsing by Author "Sharpless, KB"

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    Synthesis of 1,4-triazole linked zanamivir dimers as highly potent inhibitors of influenza A and B
    (The Royal Society of Chemistry, 2012-11-29) Fraser, BH; Hamilton, S; Krause-Heuer, AM; Wright, PJ; Greguric, I; Tucker, SP; Draffan, AG; Fokin, VV; Sharpless, KB
    The copper catalyzed azide alkyne cycloaddition (CuAAC) reaction – the quintessential ‘click’ reaction – was used to synthesise dimers of the neuraminidase inhibitor zanamivir in high yields. The effect upon anti-viral activity of varying the linker length and the number of triazole units was explored. All dimers were tested for anti-viral activity against influenza A/Sydney/5/97 and B/Harbin/7/94 in a cytopathic effect (CPE) assay. © Royal Society of Chemistry