Browsing by Author "Preston, D"

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    Investigating the cytotoxicity of platinum(II) complexes incorporating bidentate pyridyl-1,2,3-triazole “click” ligands
    (Elsevier B.V., 2016-12-01) Pages, BJ; Sakoff, J; Gilbert, J; Zhang, Y; Li, F; Preston, D; Crowley, JD; Aldrich-Wright, JR
    Six platinum(II) complexes of the type [Pt(PL)(AL)]2 +, where PL is a bidentate pyridyl-1,2,3-triazole “click” ligand and AL is the R,R or S,S isomer of 1.2-diaminocyclohexane, have been synthesised and characterised by several methods including elemental microanalysis, proton NMR spectroscopy and X-ray crystallography. The in vitro cytotoxicity of each complex was assessed in eleven cell lines, revealing moderate to good activity for complexes incorporating 2-(1-phenyl-1H-1,2,3-triazol-4-yl)pyridine. © 2016 Elsevier B.V.