Browsing by Author "Lindoy, LF"
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- ItemInvestigation of novel bis- and tris-tetraazamacrocycles for use in the copper-64 (Cu-64) radiolabeling of antibodies with potential to increase the therapeutic index for drug targeting(American Chemical Society, 2009-05) Ramli, M; Smith, SV; Lindoy, LFThe 64Cu complexes of a series of mono-, bis-, and tris-tetraazamacrocycles have been prepared, and their stability in human sera has been assessed. The ligands forming the most stable Cu2+ complexes were then conjugated to the B72.3 antibody (mAb). Conditions for conjugation of the ligands to the mAb were optimized for the concentration of protein, ligand, pH, temperature, and time. The optimum moles of Cu2+ attached to the mAb were as high as 3.5 for L2 and 5.5 or 2.7 for L5, and the immunoreactivity was ≥80%. Biodistribution of the radioimmunoconjugates showed good tumor localization and target-to-background ratios that were significantly enhanced compared to those achieved with monotetraazamacrocyclic derivatives. © 2009, American Chemical Society
- ItemA large spin-crossover [Fe4L4]8+ tetrahedral cage(Royal Society of Chemistry, 2015-05-20) Li, L; Saigo, N; Zhang, YJ; Fanna, DJ; Shepherd, ND; Clegg, JK; Zheng, RK; Hayami, S; Lindoy, LF; Aldrich-Wright, JR; Li, CG; Reynolds, JK; Harman, DG; Li, FA large discrete face-capped tetranuclear iron(II) cage, [Fe4L4](BF4)8·n(solvent), was synthesised via metal-ion directed self-assembly. The cage is formed from a rigid tritopic ligand that incorporates chelating imidazole-imine functional groups. The cage displays temperature induced spin-crossover and LIESST effects and is amongst the largest iron(II) tetrahedral cages with such properties reported. The synthesis, structure and magnetic properties of this new metallo-cage are presented. © 2015 The Royal Society of Chemistry
- ItemSelf-assembly of a unique 3d/4f heterometallic square prismatic box-like coordination cage(Royal Society of Chemistry, 2016-05-23) Li, L; Zhang, Y; Avdeev, M; Lindoy, LF; Harman, DG; Zheng, RK; Cheng, Z; Aldrich-Wright, JR; Li, FAbstractWe present the synthesis and characterization of a unique, slightly distorted square prismatic, box-like coordination cage of type [Cu6Dy8L8(MeOH)8(H2O)6](NO3)12·χsolvent obtained via the supramolecular assembly between a non-centrosymmetric Dy(III) metalloligand and Cu(II) nitrate. Magnetic susceptibility measurements indicate that the complex behaves as a single-molecule magnet. © 2016 Royal Society of Chemistry
- ItemSynthesis and characterisation of new tripodal lanthanide complexes and investigation of their optical and magnetic properties(Royal Society of Chemistry, 2017-08-21) Craze, AR; Huang, XD; Etchells, I; Zheng, LM; Bhadbhade, MM; Marjo, CE; Clegg, JK; Moore, EG; Avdeev, M; Lindoy, LF; Li, FThis paper presents the synthesis of a tripodal ligand (H3L) via the Schiff base condensation of N,N-diethylsalicylaldehyde and tris(2-aminoethyl)amine. The neutral complexes of type [EuL], [GdL] and [DyL] were synthesized and characterized by FT-IR, SEM-EDS, PXRD, single crystal X-ray diffraction, CHN analysis and high resolution ESI-MS. X-ray crystallographic studies demonstrated that the heptadentate ligand incorporating a cavity pre-organized by hydrogen bonding binds the Ln(III) ions to yield a face capped octahedral coordination geometry with three-fold symmetry. Photoluminescence studies show a typical Ln(III) absorption character for the three complexes, with [EuL] demonstrating considerably stronger lanthanide-based luminescence peaks, and a Eu(III) centered luminescence lifetime of 0.144 ± 0.01 ms. Temperature/field-dependent DC and temperature/frequency-dependent AC magnetic measurements carried out for the Dy(III) complex indicated obvious magnetic anisotropy and suggested slow relaxation behaviour with considerable quantum tunnelling of the magnetization contribution. © The Royal Society of Chemistry 2017