Browsing by Author "Lambrecht, RM"

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    Development of a titanium tungstate-based 188W/188Re gel generator using tungsten of natural isotopic abundance
    (Elsevier Science Ltd, 2002-11-01) Dadachov, MS; Le, VS; Lambrecht, RM; Dadachova, E
    The feasibility of developing titanium tungstate-based 188W/188Re gel generator using tungsten of natural isotopic abundance irradiated in a moderate flux reactor has been investigated. Influence of temperature, pH and eluent concentration on generator performance was studied. It was found that ‘‘post-formed’’ approach allows to construct gel generators with elution performance and 188Re elution yields very close to those of conventional alumina 188W/188Re generator. Curie-level 185W radionuclidic impurity presents a challenge during the processing of target material and subsequent elution of the generator. In the future use of semi-enriched with 186W target material (50–60% enrichment) would be beneficial in the development of titanium tungstate-based 188W/188Re gel generators. 2002 Elsevier Science Ltd.
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    Development of alternative technologies for a gel-type chromatographic Tc-99m generator
    (Wiley-Blackwell, 1994-04-01) Le, VS; Lambrecht, RM
    There is continuing concern worldwide about the need for multiple sources of the 99Mo generator, and the large investment required to introduce the use of 235U (n, f) 99Mo derived production at a mew facility. This is sufficient justification required for research on the development of technologies for a gel-type chromatographic 99mTc generator based on the 98Mo(n,r)99 Mo nuclear reaction. The synthesis of Titanium-Molybdate (abbrev. TiMo) generator packing gel pre-formed for 98Mo(n,r)99 Mo neutron activation of TiMo; and Zirconium-Molybdate (abbrev. ZrMo) gel columns containing (n,r) produced 99Mo for preparation of chromatographic 98mTc generators was studied. The chemistry of polymerisation, and amorphous or crystalline TiMo and ZrMo formating of the molybdate polyanion was investigated for the interpretation of the 99mTc-elution performance from the gel generators. Preparatory conditions of TiMo and ZrMo were found to be very critical. The complexity in the preparation of TiMo and ZrMo is attributed to the large capability of polymeric hydroxl complexes of Ti+4 and Zr+4 ions in the aqueous solution. The preparation of TiMo and ZrMo requires a process of high standardisation to give a product of consistent quality. X-ray diffraction patterns of the MoTi gel were similar between batches. Behaviours, such as target temperature, irradiation stability, and neutron self-shielding, of the TiMo gel under reactor irradiation conditions that effect the performance of the generator and the quality of the 99mTc pertechnetate elucate were measured. The specifications of TiMo and ZiMo gel columns of high 99mTc elution performance, and chromatographic 99mTc generator options yielding 99mTc fulfilling the requirements for nuclear medicine applications with several conventional kits will be illustratively described. The eluents used in the generator options are saline, redistilled water, or even organic solvent such as acetone, MEK. Fifty gel generators this type were tested in different hospitals in Vietnam, and gave satifactory results. The gel generator concept is particularly relevant to hospitals in developing countries that do not have access to fission produced 99Mo generators. Also a satisfactory gel-type generator based on (n,r)99 Mo Should be economical to produce. © 1994, Wiley-Blackwell
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    Progress in radiopharmaceutical development in the Australasia region
    (The Institution of Engineers Australia, 1994-05-01) Lambrecht, RM; Katsifis, A; Kassiou, M; Smith, SV
    Recent progress in the development of reactor and cyclotron produced radionuclides, conversion to precursors, synthesis, quality control and biomedical applications are highlighted with examples of prospective radiopharmaceuticals applicable to major diseases of the Australasia region. The merits of cyclotrons and nuclear reactors for medical radioisotopes in the region are cited