Browsing by Author "Jansen, M"

Now showing 1 - 2 of 2
  • Thumbnail Image
    Item
    High-density lipoprotein function is modulated by the SARS-CoV-2 spike protein in a lipid-type dependent manner
    (Elsevier B. V., 2023-09) Correa, YB; Del Giuduce, R; Waldie, S; Thépaut, M; Gerelli, Y; Moulin, M; Delauney, C; Fieschi, F; Haertlein, M; Le Brun, AP; Forsyth, VT; Moir, M; Russell, RA; Darwish, TA; Brinck, J; Wodaje, T; Jansen, M; Martín, C; Roosen-Runge, F; Cárdenas, M; Micciulla, S; Pichler, H
    There is a close relationship between the SARS-CoV-2 virus and lipoproteins, in particular high-density lipoprotein (HDL). The severity of the coronavirus disease 2019 (COVID-19) is inversely correlated with HDL plasma levels. It is known that the SARS-CoV-2 spike (S) protein binds the HDL particle, probably depleting it of lipids and altering HDL function. Based on neutron reflectometry (NR) and the ability of HDL to efflux cholesterol from macrophages, we confirm these observations and further identify the preference of the S protein for specific lipids and the consequent effects on HDL function on lipid exchange ability. Moreover, the effect of the S protein on HDL function differs depending on the individuals lipid serum profile. Contrasting trends were observed for individuals presenting low triglycerides/high cholesterol serum levels (LTHC) compared to high triglycerides/high cholesterol (HTHC) or low triglycerides/low cholesterol serum levels (LTLC). Collectively, these results suggest that the S protein interacts with the HDL particle and, depending on the lipid profile of the infected individual, it impairs its function during COVID-19 infection, causing an imbalance in lipid metabolism. © Crown Copyright 2023. Published by Elsevier Inc. Open Access - CC BY licence 4.0.
  • Thumbnail Image
    Item
    Revised description of the early Permian recumbirostran “Microsaur” nannaroter mckinziei based on new fossil material and computed tomographic data
    (Frontiers, 2021-09-22) MacDougall, MJ; Seeger, R; Gee, B; Ponstein, J; Jansen, M; Scott, D; Bevitt, JJ; Reisz, RR; Fröbisch, J
    The early Permian Richards Spur locality of Oklahoma has produced abundant material of numerous terrestrial fossil tetrapods, including various “microsaurs,” several of which are considered to belong to the clade Recumbirostra. We present a new partial skull of the recumbirostran “microsaur”Nannaroter mckinziei; through computed tomography (CT) analysis of both this new specimen and the holotype, we provide an updated description of the taxon. This new description provides novel information regarding several regions that could not be examined previously due to either being absent in the holotype or difficult to access. This includes missing and obscured aspects of the skull roof, braincase, lower jaw, and the palatal region. Furthermore, the new information obtained from this description was used to update phylogenetic character codings ofNannaroter, and a revised phylogenetic analysis was conducted. The results of this updated analysis are congruent with those of other recent phylogenetic analyses of recumbirostran “microsaurs.” This new information adds to the ever-growing body of early tetrapod CT data, which has been, and will continue to be, important in revealing details regarding early tetrapod anatomy, interrelationships, paleoecology, and evolution. © 2021 MacDougall, Seeger, Gee, Ponstein, Jansen, Scott, Bevitt, Reisz and Fröbisch. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).