Browsing by Author "Ippolitov, YA"

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    Spectroscopic examination of dentine and gingival fluids and their diagnostic capability for the preventive treatment of pathology carious processes in dentine
    (Institute of Physics Publishing, 2019-10-22) Seredin, PV; Goloshchapov, DL; Ippolitov, YA; Vongsvivut, JP
    Abstract. IR-spectra of the samples of the dentine and gingival fluids obtained with the use of synchrotron radiation can be applied for the diagnostics of the pathological processes of the caries character in a dentine. Vibrations within the range of 2100-2050 cm-1 observed in the spectra of dentine and gingival fluids characteristic of thiocyanates mean the development of the carious pathology. At the same time vibration modes of the carboxyl group of a complex ether detected within the range of 1765 – 1725 cm-1 in the spectra of dentine and gingival fluids certainly confirm the development of caries in dentine. These spectrometric signatures can be certainly and reliably detected also in the gingival fluid, indicating at the fact that the changes proceeding in its molecular composition are referred just to the development of pathological processes in the deep dental tissues. © The Authors - Open Access CC-BY Licence by IOP Publishing Ltd.
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    The study of molecular composition in biomimetic interface of biocomposite/dentin
    (Institute of Physics, 2021-12-06) Goloshchapov, DL; Kashkaro, VM; Ippolitov, IY; Ippolitov, YA; Nikitkov, K; Vongsvivut, JP; Seredin, PV
    The aim of the study is the problem of formation of the biomimetic interface between the dental product and dentin of the human tooth as well as the investigations of molecular-chemical features in biointerface with the use of molecular multivariate IR-visualization. The data on synchrotron IR-mapping made enabled to differentiate the regions of sound dentin tissue and biomimetic transition layer and also to determine molecular groups responsible for the process of integration. © 2021 The Authors by IOP Publishing Ltd. Open Access - CC-BY 3.0 licence
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    Synchrotron IR-microspectroscopy-based visualization of molecular and chemical interactions between dental cement, biomimetic composite and native dental tissue
    (Pirogov Russian National Research Medical University, 2019-08-01) Goloshchapov, DL; Kashkarov, VM; Ippolitov, YA; Ippolitov, IY; Vongsvivut, JP; Seredin, PV
    The low affinity of composite materials for the hard tissue of human teeth poses a challenge to restorative dentists. This study was undertaken to explore molecular and chemical characteristics of the interface between the dental cement, the buffer layer formed from a next generation biomimetic material that mimics the organic mineral composition of human enamel and dentin, and the intact native hard dental tissue. Seven plane-parallel dental slices were analyzed using synchrotron IR microspectroscopy. The obtained absorption spectra of functional molecular groups were organized into cluster maps. This allowed us to identify the intact tissue, the adhesive agent and the biomimetic layer at their interface and to localize and measure concentrations of functional groups involved in the integration of the biomimetic composite into the hard tissue of the human tooth. The proposed biomimetic material is based on nanocrystal carbonate-substituted calcium hydroxyapatite synthesized from a biogenic calcium source and a complex of basic polar amino acids copying the composition of the human tooth and can form a functional bond with hard dental tissue. © 2019 The Authors. Open access under Creative Commons Attribution 4.0 International (CC BY 4.0) License.